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실험실

실험실

재생유전학 실험실(지도교수 윤동석)

[Regenerative Genetics Laboratory]

The Regenerative Genetics Lab at Yeungnam University’s Department of Medical Biotechnology focuses on innovative research in cellular regeneration and anti-aging. We utilize mesenchymal stem cells and chondrocytes to develop advanced gene therapies and regenerative strategies. Our primary goal is to develop novel biological drugs for osteoarthritis and osteoporosis using disease models.
We also specialize in cell reprogramming to rejuvenate aged cells, combining gene delivery and small molecule approaches. Our lab provides an interdisciplinary environment for training future experts in regenerative medicine.

  • Objective: Develop advanced cell and gene therapies for Osteoarthritis and Osteoporosis.
  • Strategy:
    • Utilize gene-modified Mesenchymal Stem Cells (MSCs) to enhance bone and cartilage repair.
    • Validate therapeutic efficacy using an in vitro inflammation model of chondrocytes.
  • Goal: Achieve functional regeneration of damaged cartilage and bone tissues.
  • Objective: Reverse aging strategies by partial cellular reprogramming.
  • Strategy:
    • Apply cellular reprogramming to aged cells.
    • Maximize rejuvenation by exploring the synergy between gene delivery (e.g., OSK) and small molecules.
  • Goal: Restore youthful function to aged cells and develop therapies for age-related diseases.

Selected Recent Publications by the PI

  • Age-Related Decrease in Pellino-1 Expression Contributes to Osteoclast-Mediated Bone Loss

    Advanced Biology, 2024

  • Downregulation of the RNA-binding protein PUM2 facilitates MSC-driven bone regeneration and prevents OVX-induced bone loss

    Journal of Biomedical Science, 2023

  • RUNX2 stabilization by long non-coding RNAs contributes to hypertrophic changes in human chondrocytes

    Internation Journal of Biological Sciences, 2024

  • Diabetic bone regeneration with nanoceria-tailored scaffolds by recapitulating cellular microenvironment: Activating integrin/TGF-β co-signaling of MSCs while relieving oxidative stress

    Biomaterials, 2022

  • TLR4 downregulation by the RNA-binding protein PUM1 alleviates cellular aging and osteoarthritis

    Cell Death and Differentiation, 2022